Health Benefits Of Dim (3,3′-diindolylmethane)

What is DIM?

Cruciferous vegetables such as Brussels sprouts, cauliflower, cabbage, and broccoli contain plant substances that make DIM in the body.. It is a form of Indo;e-3-Carbinol (I3C) which is highly concentrated in vegetables from the Brassicaceae family.

This supplement is used for a range of treatments and shows diverse medical properties. The US National Cancer Institute has begun human trials on a large scale addressing the supplement’s potentials for fighting cancer.

DIM is a phytonutrient with properties that can affect the body’s production of estrogen metabolites. When it is taken orally, DIM creates a healthy balance of estrogen in the body by reducing the production of 16-hydroxy ‘bad’ estrogen and increasing 2-hydroxy ‘good’ estrogens.

This has benefits in both men and women. In women, it may help improve PMS symptoms, support weight loss and improve symptoms of menopause. In men, it may help prevent feminization such as the formation of male breast tissue.

DIM has also been found to have anti-cancer effects. Over twenty years ago, it was discovered that women with uterine or breast cancer often have high levels of the 16-hydroxy type and low levels of the 2-hydroxy type.

In some animal tests, DIM showed the ability to inhibit angiogenesis which is the process through which blood vessels are formed so as to deliver nutrients to cancerous cells and is a necessary step for the growth and survival of cancer cells. DIM can slow down cancers by inhibiting these new blood vessels from forming.

Estrogen levels can increase due to a number of factors including obesity, genetics, poor diet and interaction with estrogenic chemicals or toxins in the environment.

To help fight this, DIM supplements together with Indole-3-Carbinol are suggested to restore a healthy estrogen balance and reduce the risk of estrogenic cancers.

DIM is also hailed for its anti-inflammatory properties, therefore, providing relief for symptoms of arthritis. As much as it can be shown that DIM reduces the symptoms of arthritis, there has been no indication that it can prevent it.

Much of what can be said about the therapeutic values of DIM has not yet been firmly established and backed by clinical experimentation. However, there is some data that shows the therapeutic promise of DIM such as :

A 2mg daily dose of DIM seemed to improve the HPV status in women with moderate to severe cervical dysplasia as compared to placebo group subjects.

A 600mg daily dose of DIM showed a significant decrease in prostate-specific levels of antigens in patients with prostatic adenocarcinomas.

DIM therapy is currently being used by Western doctors in the treatment of Recurrent Respiratory Papillomatosis (RRP). This is a condition where tumors develop in the upper respiratory tract caused by HPV.

DIM side effects

2 to 24mg of DIM is already contained in our daily diet therefore for clinical studies using these doses, they are considered safe. However, it has been found that with doses of 300mg and higher, headaches and stomach upset were experiences, High doses for prolonged periods of time is probably unsafe.


  1. Facts About DIM and Men’s Health. Whole World Botanicals – Source
  2. Cancer Protective Supplements. Dr Weil – Source
  3. DIM/IC3 Supplementation Blocks Estrogen, Dihydrotestosterone & mTOR. David Sautter – Source
  4. Can a Pill Offer the Same Benefits as Broccoli?. Dr. Mercola – Source

Leave a Reply

Your email address will not be published. Required fields are marked *